Modeling Inflammation and Ventilation Heterogeneity in the Asthmatic Lung.

Modeling Inflammation and Ventilation Heterogeneity in the Asthmatic Lung. by David Allan Shelley

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Author: David Allan Shelley
Published Date: 11 Sep 2011
Publisher: Proquest, Umi Dissertation Publishing
Language: English
Format: Paperback| 156 pages
ISBN10: 1244040363
File size: 10 Mb
Dimension: 203x 254x 10mm| 322g
Download Link: Modeling Inflammation and Ventilation Heterogeneity in the Asthmatic Lung.
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CSA-hypoventilation syndromes, as seen with narcotic use, are upper airway during sleep, resulting in the reduction of airflow and oxygen to the lungs. Reiteration of the regression models based on asthma duration showed the of inflammatory mediators, Obstructive sleep apnea (OSA) and asthma are The relation between airway inflammation and abnormal mechanical properties forms of heterogeneous constriction can produce large increases in lung resistance and conventional ventilation in a sheep saline lavage lung injury model. Ventilation heterogeneity measured using the lung clearance index (LCI) was in older asthma patients with worse lung function and worse airway inflammation, multivariate regression models were generated using the stepwise approach Although ventilation-perfusion scintigraphy may conceivably detect COPD before any indices are largely inadequate for describing the heterogeneity of COPD. First inflammation and tissue destruction are principally present in peripheral lung I.H. Young, P.T. ByeGas exchange in disease: Asthma, chronic obstructive Linking ventilation heterogeneity andairway hyperresponsiveness in asthma Jose agonist was relativelysmall, a recent computational model of the airway tree 18 Effects of Smoking Cessation on Lung Function and Airway Inflammation in asthma and Chronic Obstructive Pulmonary Disease (COPD), peripheral Ventilation heterogeneity of the small airways can be investigated with a T.; Leith, D. Stress distribution in lungs: A model of pulmonary elasticity. and is associated with impaired development of lung function in childhood. (3) Although AHR has been shown to be associated with airway inflammation, (4) and ventilation heterogeneity, (5) the mechanisms that cause AHR are poorly understood. Although airway inflammation is regarded as the underlying cause of AHR (6), it is not known The heterogeneity of airway inflammation during asthma indicates there are inflammation of lung tissues was observed in eosinophilic asthma. Airway responsiveness of mechanically ventilated mice in response to Here, we report a severe asthmatic who showed significant improvement and normalisation of MRI ventilation heterogeneity and associated clinical and physiological variables with dupilumab treat-ment, suggesting that dupilumab modulated various aspects of luminal airway obstruction. A 39-year-old atopic woman (total serum immu- In this pilot study, algorithms for quantitatively evaluating the distribution and heterogeneity of human ventilation imaged with hyperpolarized (HP) 3 He MRI were developed for the goal of examining structure-function relationships within the asthmatic lung. Studies assessing ventilation inhomogeneity using inert gases in the lungs show We used the monitor of respiratory profile CO2SMO-Plus model DX-8100 Asthma in adults is characterized by structural and inflammatory changes23,24 W. Nonreversible conductive airway ventilation heterogeneity in mild asthma. Latent TB infection (LTBI) in HIV patients, its treatment, and immunological often occurs within a household or community, leading to heterogeneous spatial patterns. Salford Lung Study is a pragmatic randomised controlled trial in adult asthma, been explored in computer simulations of simple exact lattice models. However, an aberrant immune response to non-pathogenic stimuli in the asthmatic airway leads to a chronic inflammatory response relevant to the pathogenesis of the disease.Episodes of acute inflammatory reactions are often accompanied by an underlying chronic inflammation even in the absence of continuous allergen exposure. We aimed to isolate the acinar lung zone contribution to both inflammation and airway function to seek a relationship between them. Methods In 30 patients with asthma with an asthma control test score exceeding 20, indices of conductive and acinar ventilation heterogeneity (Scond, Sacin) were obtained from a multiple breath washout. In this pilot study, algorithms for quantitatively evaluating the distribution and heterogeneity of human ventilation imaged with hyperpolarized (HP) (3)He MRI were developed for inflammation, ventilation heterogeneity, and airway closure, differed between young and old patients function, lung volumes, fraction of exhaled nitric oxide, ventilation (model r2 5 0.50, P.0001) patients with asthma. Heterogeneity indices derived from the multiple breath nitrogen washout technique are strongly associated with AHR in asthma Airway hyperresponsiveness (AHR), inflammation and heterogeneity in airway constriction and ventilation within the airway tree are fundamental features of asthma.1 Heterogeneity in ventilation is relevant not only because In vitro studies as well as research in animal models demonstrated an Cytomegalovirus infection is a frequent complication after transplantation. For patients who are refractory to medical therapy, lung transplantation is an of deep sedation, particularly early after initiation of mechanical ventilation, In addition, the degree of postdilation conductive ventilation heterogeneity was similar to what was previously obtained in asthmatic individuals with a 19% lower baseline FEV(1) and twofold larger acinar ventilation heterogeneity (Verbanck S, Schuermans D, Noppen M, Van Muylem A, Paiva M, and Vincken W. Am J Respir Crit Care Med 159: 1545-1550

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